"Neofilin" (tablets): imiyalelo ukusetyenziswa. "Neofilin 100 mg": inkcazelo yokulungiselela

Kuba unyango lwesifo yemiphunga esibangelwa spasm ye phecana yokuphefumla, isetyenziswa bronchodilators iqela Methylxanthine. engundoqo ngummeli wabo ngayo theophylline kweziyobisi.

Oku kusekelwe iziyobisi sokunceda ukuhlaselwa ngumbefu somoya inyumoniya, iphika obstructive kunye belele.

inkcazelo amayeza

Le medicament (Amacwecwe) imiyalelo ukusetyenziswa njengendlela medicament esibonakala abakhutshwa zoxubo Ukrainian beqinile "Darnitsya" ngeedosi ezimbini "Neofilin": 100 300 mg. Eli chiza nomphumo elide.

Ukusebenza komzimba

Le esisebenza beziyobisi (theophylline) kunempembelelo bronchodilatory kwi eziphilayo ukuvimbile apho receptors adenosine elinganeno phosphodiesterase kwandisa umxholo kweminquba intracellular, kusehla lwee- ion calcium. It uvuleka umsipha kwamagingxi kwi bronchi, iphecana zesisu, iphecana biliary, wesibeleko, coronary, pulmonary, neempahla Palsy komlomo nemithambo yenhliziyo, ukuncipha resistance peripheral nemithambo.

Phantsi yempembelelo beziyobisi waphawula ukwanda nethoni yelo zezihlunu nokuphefumla, eziquka izihlunu intercostal kunye uvalo. Ukongeza, kunciphise ukumelana yemiphunga semithambo, uphucula oxygenation esihlambo igazi, ukusebenza kweziko nokuphefumla kwi Oblongata Medulla, kwandisa susceptibility wayo carbon dioxide, ukuphuculwa umoya alveolar.

Oku kunciphisa ubungozi nezihlandlo zokumisa kunciphisa iintshukumo zemiphunga. kuqulunqo Theophylline "Neofilin" (tablets) umyalelo ncwadi yemigaqo ichaza njengoko indlela yokususa vasoconstriction, ukwandisa akananto igazi neoksijini Ukwanda igazi, nokuncipha nokudumba kwengqondo perifocal kunye jikelele, utywala unciphiso kunye noxinzelelo intracranial.

Le medicament ujoliswe ekuphuculeni iimpawu rheological igazi, nokuthintela ukuyilwa amahlwili egazi, ukunciphisa iiseli zegazi clumping bunjani microcirculation. Theophylline ukubonisa inyathelo antiallergic, apho degranulate iiseli lwemasti sehlise yoxinaniso yabalamli kukwalisa, ezifana histamine, serotonin, leukotriene.

Ngokwandisa flow igazi sezintso waphawula isiphumo umchamo apho amanzi imveliso, ion chloride kesodiyam.

Ophatha iziyobisi

Drug "Neofilin 100" manual (tablets) umyalelo icebisa ukuba ukunyanga isifuba inyumoniya, isimo somoya, iphika, obstructive uhlobo esinganyangekiyo, umphunga inyumoniya, lwegazi yemiphunga, ukubanjwa zasebusuku sokuphefumla.

Ezi ngcebiso zisebenza ezinkulu idosi chiza - 300 mg.

Indlela ukuthatha

Le medicament "Neofilin" (tablets) yemiyalezo icebisa ukuba ukuthatha idosi into uzakubekwa ngokwahlukileyo izifo ngamnye kwaye kuxhomekeke isantya lweenkqubo pathways, ubudala kunye nodidi ubunzima features nomonde.

asele Ichiza 1 Ixesha ngosuku ngexesha isidlo okanye isidlo sangokuhlwa. Medicament "Neofilin" (tablets) umyalelo ibonisa ukuba indlela engqongqo. Akunakwenzeka ngamini-nye ukuya ukusela amayeza ngexesha kwisidlo, kwaye elandelayo - emva kwesidlo.

Ukubalwa esithathwa yokususwa oluqhelekileyo sezintso

Kuba initial kunye nokulungelelanisa isixa ichiza kuyimfuneko ukuze kube nokugqitywa ngobunzulu silixabisile intlambululo yokusihlambulula plasma yegazi ukusuka izinto ezahlukeneyo nezintso.

Ukulungiselela "Neofilin" (tablets) imiyalelo ukusetyenziswa abantwana ukusuka kwiminyaka eli-12 ukuya kweli-15 ubudala kunye ubunzima nomzimba ngaphantsi kwama-45 kg Kucetyiswa ukuba basebenzise iimini ezintathu zokuqala unyango kwi idosi yemihla ngemihla ye-12 ukuya kwi-14 g 1 kg ubunzima bomzimba ngalinye. Kodwa awukwazi ukuthatha mg ngaphezulu kwama-300 beziyobisi.

Emva kweentsuku ezintathu nyango phantsi umthamo yesiqhelo kunyanyezelwa yemihla ngemihla landile ukuya ku-16 mg 1 kg ubunzima nganye. Kodwa akufuneki ngaphezu 400 mg ngosuku.

Emva ezinye iintsuku ezintathu phantsi ukunyuka ithamo kunyanyezelwa eqhelekileyo 20 mg 1 kg ubunzima nganye. Kodwa ngoku akufunekanga ibe ngaphezulu kwama-600 mg.

Ukulungiselela "Neofilin" (tablets) imiyalelo ukusetyenziswa yabantwana ababudala buli-16 abantu abadala kunye neminyaka engama-60 ubudala kunye ubunzima inomzimba ongaphezulu kwama-45 kg kwiintsuku ezintathu zokuqala zonyango ucebisa kusetyenziswa isixa-mali ka-300 ukuya 400 mg ngosuku ngomlomo.

Emva kweentsuku ezintathu phantsi ukunyuka ithamo kunyanyezelwa eqhelekileyo 400-600 mg.

Emva kweentsuku ezintathu, phantsi kweemeko ezifanayo idosi yemihla ngemihla ukuze ngaphezu 600 mg, kodwa kufuneka ukuba ukumisela ulawulo theophylline yoxinaniso egazini yesigulane.

Ukubalwa esithathwa kunye sokucoceka kakuhle kwezintso kunye abadala

babevuma njani ezinye iindidi izigulane ichiza "Neofilin" (tablets)? Imiyalelo abantwana ekucetyiswa ukufumana oko idosi, ekufuneka abe ngaphezulu kwe-16 mg ngalinye 1 kg ubunzima bomzimba ngosuku, kodwa akukho mg ngaphezulu kwama-400 xa zizonke. Ezi ngcebiso zisebenza abafikisayo ukusuka kwiminyaka eli-12 ukuya kweli-15 kunye namazinga kakuhle ukucoca kwezintso, okanye xa engekho ubuchule ukulandelela plasma uyazikhomba theophylline.

Lokulungiselela "Neofilin 300" (tablets) imiyalelo ukusetyenziswa iquka datha ilandelayo. Bathi Okuyinkxalabo ukusetyenziswa kweziyobisi elivisayo emva kweminyaka eli-16, kwaye izigulane abadala kunye namazinga kakuhle kwezintso ukucoca, kwakunye nabantu abangakwaziyo kulinganiswa plasma abasuka theophylline. Ngokuqhelekileyo ngenxa iindidi ezinjalo lwezigulane isixa isithako esebenzayo ichiza akayi kufuneka ngaphezu 400 mg.

Umthamo Ukubalwa plasma abasuka theophylline

Kuxhomekeka umxholo isithako esisebenzayo kwi plasma yenziwa ulungiso idosi "Neofilin 100" (tablets). Imiyalelo isenzo esinjalo kufuneka ukuvelisa xa uthatha amathamo aphezulu amayeza. Nciphisa izinga isithako esebenzayo ukulawula isixa serum kuyimfuneko xa kuthe reactions ezibi, ukuphazamiseka komzimba, apho abangaphangeliyo ukuba kukhuthaza ichiza.

Ukuba xi incopho theophylline egazini kuba ngaphantsi kwe 9.9 g ngalinye 1 ml, ukunqongophala nefuthe medicament kwi ukunyamezelana eqhelekileyo kufuna ulwando lwama-25 ekhulwini balawule. Emva kweentsuku ezintathu, kuba ukutshintsha imali elandelayo ichiza kuthwalwa plasma uyazikhomba theophylline.

Ukuba isiphumo unyango kunye tolerability kuza olulungileyo kunyango endala ithamo ngakumbi kunokwenzeka kuphela emva kokuba ukumiselwa plasma lamanani isithako esebenzayo. Kule nani kufuneka ibe ezahlukeneyo ukususela micrograms-10 ukuya 14.9 nganye 1 ml. Ukuba akukho ndlela, kodwa nakho ukuguqulwa ilungile, wongezelela kwamanye amayeza.

Xa ithamo kufuneka incitshiswe

Xa ukufumaneka plasma theophylline ku ezahlukene micrograms-15 ukuya 19.9 ml nganye, ifuna ukuncitshiswa idosi ye-10%.

Xa micrograms Isalathisi kweziyobisi 20 ukuya 24.9 ml nganye kuyimfuneko kukunciphisa isixa isiyobisi 25%, nokuba akukho khemikhali ezibi ibonakale. Emva kweentsuku ezintathu emva kokuba unciphiso idosi yenziwa iliso Isalathisi plasma theophylline ukusetyenziswa kunokwenzeka ngakumbi ichiza.

Ukuba inqanaba into esebenzayo uvela 25 ukuya 30 g nganye 1 ml, ukufumana Umthamo okulandelayo udlule, kunye nokunciphisa inani eyimfuneko medicament-25%.

Emva kweentsuku ezintathu emva kokuba unciphiso idosi yenziwa iliso Isalathisi plasma theophylline ukujonga ukusetyenziswa kwixesha elizayo ichiza. Ukuba iimpawu yemiphumela emibi kunokwenzeka, athathe amanyathelo afanelekileyo.

Xa uyondelelwano lwee- theophylline egazini mkhulu 30 micrograms nganye 1 ml kungenzeka overdosing. Kuba umthamo isicelo ngakumbi kuncitshiswa ngesiqingatha. Kwiintsuku ezintathu kamva, kuthwalelwa phandle umntu kwakhona nesilinganiso isixa ichiza plasma kunye idosi echanekileyo.

Iimpawu ze isicelo

isicelo Xa ofumana itshaya "100 Neofilin" macwecwe Umsebenzisi ulumkisa malunga ukuncitshiswa isiphumo unyango kunokwenzeka.

Kuba abantu abanezifo kakhulu intliziyo, imithambo yegazi, isibindi, usuleleko wentsholongwane egazini, ebudaleni idosi hlengiswe ngamnye kwaye uthathe amayeza kwezi meko ngononophelo kakhulu.

iziyobisi kwemfuneko

Xa izigulane abadala, iyeza libanda, "Neofilin 300" (tablets) manual ichaza amahlaba, ifiva, Izitenxo intliziyo, kuquka tachycardia, arrhythmia ventricular, hypotension.

Iimpawu uphawu ebuntwaneni, iquka ucaphuka kakhulu, ukuphazamiseka ubuntu, ifiva, isicaphucaphu, chaza convulsive, tachycardia, hypotension, ngayo inhliziyo sokuphefumla.

Ukuza kunyanga kufuneka kuqala bayeke ukuthatha ipilisi, ngoko ahlambe isisu, amathumbu ukunkcenkceshela indibaniselwano ityuwa kunye polyethylene ethers, ukuthatha namalahle. Lithethelela ukuba imvume theophylline ukukhuthazwa igazi ngendlela diuresis ngenkani, hemosorption, plasma sorption, wehemodialysis, dialysis peritoneal.

Kwimeko isicaphucaphu nokugabha nomonde alawulwa arhente kwangumqondiso, umzekelo, ulwamkelo "Ondansetron" okanye "MCP". Ukuphelisa uhlaselwe uyakwazi ukufumana 'Diazepam ".

Ngubani na ukuthatha

Xa Elungiselela "Neofilin 100" (tablets) umyalelo iquka uluhlu Izimo, nto leyo enganakho ukwenzeka xa amayeza. Ezi ziquka i uvakalelo olwandisiweyo onke amacandelo kuthetha ukuba amayeza kuthotho xanthine, ezibandakanya caffeine, theobromine, pentoxifylline.

Ayikwazi amkelwe acute umsipha engabalulekanga engabalulekanga mihle, tachyarrhythmias, cardiomyopathy hypertrophic obstructive, lwegazi kakhulu, sokuwa, hyperthyroidism, isilonda Peptic esiswini okanye duodenum, ukuphazamiseka kakhulu kwesibindi, porphyrin izifo.

Kuthethwa contraindicated abantwana abangaphantsi kweminyaka eli-12 ubudala.

ukusabela ezingalunganga

Iqela ziziphumo ebezingalindelekanga aba lolwamkelo esikolweni "Neofilin" ukulungiselela (tablets). Imiyalelo yokusebenzisa idlulisa izigulane kunye nolwazi malunga nokwenzeka ukuphazamiseka kwisiqwenga zesisu. Bona luphawulwa iintlungu esiswini, isicaphucaphu, reflex gag, reflux gastroesophageal, heartburn, ukuqhubela phambili izilonda, urhudo, yehle onombilini.

abasabela Ezingalunganga kubonakala yegazi ngohlobo iyangongoza, tachycardia, arrhythmias kwentliziyo, bemthoba uxinzelelo lwegazi, angina lobuxoki, sifuba angina.

Theophylline abe nefuthe kwinkqubo luvo. Oku kungenziwa ababalulwa nesiyezi, intloko ebuhlungu, chaza angonwabi okanye ichulumancile, yokulala, lafa, ingqondo, unditsho nokuxutha izinto.

Phambi ichiza kukwalisa lubandakanywe nezenzo yabangxamayo eluswini, erythema, dermatitis exfoliative, urticaria, nomkhuhlane.

Ezinye iziphumo engathandekiyo zonyango ziquka ilahleko kweenwele entlokweni, iintlungu esifubeni, ukuphefumla nzulu ezikhawulezayo, ukuhlisa, zinomgutyulo albumin of iiprothini umchamo, ubukho igazi nomchamo, ukwanda imveliso umchamo, ukubila eyonyukileyo kunye lobushushu ulusu.

Theophylline kuchaphazela kwi parameters elebhu. Ekunyangeni iziyobisi "Neofilin 'ukuze ukutshintsha umxholo ion potassium serum ezantsi kuphuhliso hypokalemia. Ngelo xesha linye umgangatho creatinine, ion, calcium oxalate, ezo ityuwa of uric acid neswekile siyandiswa, nto leyo ekhokelela hypercalcemia, hyperglycemia kunye hyperuricemia.

Emva wemithi medicament ukunciphisa iqondo yeziphumo ebezingalindelekanga lifinyele.

Ukukhulelwa ne zisanyisa

Amacwecwe Icandelo Active nga kudlula njengomqobo placental zidlule zibe ubisi lwebele.

ukwamkelwa kubeleka kunokwenzeka kuphela xa isiphumo sonyango umama umngcipheko mkhulu usana olungekazalwa. Kwimeko unyango olunjalo kufuneka ube yinxalenye zoqhaphelo plasma ethile theophylline, kwaye uhlengahlengiso ahambelana kuthetha of nomthamo. Engathandekiyo ezithatha ichiza kwiinyanga zokugqibela zokumitha ngenxa kwezithandani izihlunu zesibeleko.

Abasetyhini abo lwebele-eyondliwe emkhumbini kunye ziphathwe theophylline kufuneka zihlolelwe imbonakalo hypersensitivity umntwana. na uphuhliso olunokubakho of excitation okanye ukulala iingxaki, nto leyo ifuna ukupheliswa ichiza.