Prothrombin isalathiso, rate kunye nexabiso

index Prothrombin, izinga leyo ilingana no 95-105%, - yenye izikhombisi eziphawula ekunqandeni igazi. Igazi ekunqandeni - yinkqubo entsonkothileyo kakhulu oluqhutywa kunye inxaxheba ukuxubana iiprotheni eyodwa ebizwa ngokuba imiba coagulation. Ukusebenza kwale nkqubo kungenzeka ngeendlela ezimbini - bangaphakathi kunye nabangaphandle.

It index prothrombin ubonakalise ipoti ye coagulation nge endleleni extrinsic. Oko ngolu hlobo lulandelayo: waphula umthetho ingqibelelo izicwili (ngenxeba) yabelwa ekuthiwa izihlunu thromboplastin, iproteni ezikhethekileyo ezifumaneka kuzo zonke izihlunu zomzimba. It ekwenyukeni ngumbala ukuxubana leyo ufake neminye imiba amahlwili (V, VII, no X, II, I), ngokulandelelana isebenze omnye. Ekugqibeleni, ihlwili igazi ibunjiwe ukopha ime.

Yintoni i index prothrombin

izinqumisi akhiwa esibindini. Kwezi, II, V, X na vitamin K-oxhomekeke. Ngenxa yokungabikho ivithamin amagama abo iphazamisekile. Ngako oko, kukho Kukwaphula hemostasis. Ukwazi isalathiso prothrombin, nto leyo izinga eyaziwayo, ugqirha wakho angase:

1. Umsebenzi Izinga tentatively II, V, VII kunye X zinto nabo ekunqandeni
2. Ubukhulu zesi salathisi ukugweba umsebenzi kwesibindi
3. On Ukwanda vitamin K
4. Ubume ngokubanzi yenkqubo coagulation igazi
5. Ngokutsho kwesi salathisi, ungenza esweni impumelelo unyango anticoagulant.

Njengoko kumiselwe yi isalathiso prothrombin

Isalathisi Prothrombin iyamiselwa capillary okanye igazi lwemithambo. Kwimeko yesibini ukutya igazi ithatyathelwe kumbhobho uvavanyo kunye anticoagulant xa om-9: 1. Njengoko kusetyenziswa anticoagulant sodium citrate. Elabhoratri, igazi centrifuged. I-plasma ngenxa isetyenziselwa nokuzimisela kwexesha prothrombin (PT). ISithethe alo ukho kuluhlu kwisekhondi-12 ukuya ku-20, kuxhomekeke umsebenzi lo thromboplastin asetyenziswe ngexesha ukusabela elebhu.

Ukwazi PT yesigulane, unako ukubala le PI, oko kukuthi, isalathiso prothrombin, nto leyo eqhelekileyo kwiilebhu ezahlukeneyo nako ethile yanexatyiswana eyahlukileyo. Nguye ulingana umlinganiselo px mntu usempilweni ukuba isigulane PV, iphindwe 100:

PI = PV esempilweni. / SA abagulayo. X 100 (normal 95-105%)

Ukubaluleka kwe PI

Phezulu coagulation PT okanye prothrombin kabani norm lemizuzwana-12 ukuya kuma-20 bufinyeziwe, kunye nokunyuka PI. Le ingaba ngexa lokukhulelwa, kunye njengokonzakala omkhulu xa igazi kuza eninzi yethishyu thromboplastin.

Kwelinye icala, alo ukunyuka sehlise kunye nokuhla ku PI amahlwili, ezifana njengakwimeko intswelo naso zizinto kwamahlwili, kunye isifo kakhulu kwesibindi, kukho ukuswela vitamin K (ezinokuthi zenzeke kule cholestasis, dysbacteriosis, ukuphazamisa umsebenzi ethunjini). PI kuyancipha nge lwefibrinogen ephantsi okanye ukukhubazeka esebenzayo, kunye syndrome DIC, phambi kwezinto anqanda ukopha.

Yintoni INR

Unyango anticoagulants ngqo ngokwendalo kunciphisa index prothrombin. norm wayo ungaba ngokwayo yayo yonke elebhu. Ngoko ke, ukuze bakwazi ukuthelekisa iziphumo zeemvavanyo efunyenwe kweelebhu ezahlukeneyo, oko yaqalisa uvavanyo standardised ezifana INR. Esi salathisi ukubala. Oku kumiselwa ngokusekelwe lulwahlulo ixesha prothrombin yomguli, ixabiso eqhelekileyo MF kunye nesalathisi isidanga thromboplastin uvakalelo (Isi).

INR = (PT b th / MF rate) kwi iqondo Isi

Xa umntu inempilo INR kuluhlu 0, 8-1,2.

Esi salathisi isetyenziswa esweni ukusebenza anticoagulants amanyathelo. Xa unyango lwe anticoagulant xa coagulation lifinyele (umzekelo emva uqhaqho lwemiphunga yentliziyo) INR kufuneka kwandiswe ukuze 2-3. Ngenxa yokwanda INR amahlwili lifinyele. Umlinganiselo phakathi PI kunye INR nto kangangokuba nokuhla kwisalathiso PI landa INR.