"Atorvastatin": ncomo, analogs, ukwakhiwa kunye nemiyalelo yokusebenzisa

Ichiza ixhaphakileyo eyilelwe ukunciphisa amazinga cholesterol iyonke kunye LDL i "Atorvastatin". Baqinisekiswa ngayo ingacaci, nangona umgangatho imveliso ingqinwa kwizifundo zonyango. Ngelo xesha linye chiza enye kuphela okhuphisana yinxalenye - "Rosuvastatin" (kunye generics zayo). Kuba kucacile ukuba "atorvastatin" ukulungiselela angqina nomonde ukuze ukunika ulwazi njongo. Ngoko ke, ukuba ukuphonononga imiphumela yayo efunekayo uhlalutyo oluneenkcukacha indlela amanyathelo kunye nezibonelelo imiyalelo aqhotyoshelwe apha ukuze asetyenziswe.

into achaza iziyobisi oluCwangcisiweyo

Atorvastatin fanele ukuba iklasi amayeza yezizukulwana statins wesithathu. Xa ziyibuyisela umva le transcriptase onoxanduva kuyondelelaniswe iqala cholesterol, ukucutha ubuninzi atherogenic lipoprotein amaqhekeza. Low-mninzi iqhekeza (LDL) unako ukuphucula yokulahlwa kwe-cholesterol kwaye zibangela iimpendulo omzimba kwi endothelium, ngenxa apho uqweqwe asakhasayo.

Njengezinye statins, atorvastatin kunciphisa kakhulu isixa LDL, ngoko ukucola kakhulu ekukhuleni bathintele. Kule utyekelo involution yayo ayenziwanga wathi, kwaye netoti a kwemithambo (okanye nayiphi na enye atherosclerotic), uhlala okufanayo. Isiphumo lwezonyango - kuyehla uphuhliso isifo sentliziyo, cerebrovascular okanye engapheliyo emithanjeni insufficiency le nemilenze.

"Atorvastatin": zikhombisa ukuba ukusetyenziswa

Ngaphambi kokuba kufuneka ukuba ukuchaza ezibonisa ukuba ukusetyenziswa kweziyobisi gwenxa. Bona zivela indlela esisiseko amanyathelo kwaye zinxulunyaniswa nempembelelo cholesterol-lisibekele. Uluhlu kwakuthethwa:

• sofuzo (kwiintsapho) hypercholesterolemia, heterozygous;
• polygenic (primary) iklasi hypercholesterolemia IIA ngokwe Fredrickson;
• Kolimo (IIb) dyslipidemia;
• hypercholesterolemia kwiintsapho Homozygous;
• hypertriglyceridemia (unyango kunye statin nodibaniso idayethi umthambo);
• iimeko ezinxulumene izilonda atherosclerotic nemithambo eludongeni intliziyo, ingqondo, izintso, yesiqephu;
• hypertension nge emngciphekweni omkhulu sentliziyo;
• ukunqanda iziganeko zosulele coronary ngokuchasene nentsukaphi izilonda ezikhoyo atherosclerotic kwemithambo yenhliziyo;
• uthintelo engabalulekanga kwakhona iposi-okanye stroke lobuchopho.

Ezi ukufundwa ukumisela iimeko xa kufuneka ukuqeshwa "Atorvastatin" iziyobisi. Oogqirha malunga nesicelo yayo ukuqinisekisa ngokucacileyo oku. Kuyinyani bokuba ukuba statins, kuquka "Atorvastatin" kunye generics zayo ubuninzi bazo ikhuseleke kakhulu kardioform acetylsalicylic acid, nangona ngokufanayo kunceda ziyakwehlisa ngokubonakalayo amathuba okuba ekuphuhliseni iimeko zokuqala engabalulekanga iposi kunye phinda.

analogue iziyobisi

Zonke tablets "Atorvastatin", nto leyo ncomo zinokufundwa ngezantsi, enziwe kwakhona ziinkampani ezahlukeneyo zamachiza. Amaninzi, amagama amachiza ilungiswe, nto leyo evumela ukuba awodwa. Amagama Trade analogue, oko kukuthi, iziyobisi eziqulathe atorvastatin component esebenzayo, ezi zilandelayo: "Anvistat" yaye "Atokord", "Atomas" yaye "ongu-", "Atorvoks" kunye "Atoris", "Vazotor" yaye "Lipoford" "Lipitor" yaye "Liptonorm", "Novostat" yaye "Torvazin", "Torvakard" yaye "eTulip".

Kwakhona, ezinye abavelisi ukuvelisa amayeza abo "Atorvastatin" (uyakwazi ukufunda nohlolo ngezantsi) phantsi efanayo igama lorhwebo. "Actavis", "enekona", "Izvarino Pharma", "ALSI Pharma", "Canon Pharma" Obolentsenskoe Inkampani zamachiza, "Protek-SVM", "North Star", Tabuk Pharmaceuticals, TEVA Pharmaceutical Industries, kunye nabanye bavelise igama iziyobisi equka Inn ( "atorvastatin") kunye consoles yemveli. Umzekelo "Atorvastatin Teva", ncomo apho ukuqinisekisa impumelelo yayo clinical.

isakhiwo

Okuqhotyoshelwe ichiza 'atorvastatin' imiyalelo ukusetyenziswa, ncomo kunye nezikhokelo zonyango musani siqulathe ulwazi malunga ngomahluko phakathi kwezi ntlobo balawule. Ukuziqhelisa, ngaba zikhona iiyantlukwano ezinjalo, yaye ulawule ukuba Dynamics isenzo zonyango. Yintoni ebalulekileyo yindlela ngokukhawuleza uza isiphumo konwaywa idosi. Kungenxa yoko le nto kuqulunqo "Lipitor" Yiyo le incwadi beziyobisi yokuqala.

Ifom oyidlayo iquka amacwecwe calcium atorvastatin kunye iqokobhe. Nevuthisayo ngexesha ke, iqulathe calcium carbonate, microcrystalline kwincindi, monohydrate lactose, polysorbate 80, isodiyam croscarmellose, nemagnesium stearate, hydroxypropylcellulose, talc, titanium dioxide, polyethylene ethers, hydroxypropylcellulose, emulsion simetikonovoy, benzoic kunye sorbic acid.

Kuqhotyoshelwe apha yokuqala manual "Atorvastatin" umyalelo iziyobisi (izigxeko kwakhona kule ngongoma) engaphenduli iqulathe ulwazi malunga ubunzima kwicandelo ngalinye. Oku imfihlelo yorhwebo yenkampani American Pfizer HCP CORPORATION. Loo ifomu idosi "Lipitor" ikuvumela ukuba ukuphumeza yoxinaniso rhoqo atorvastatin egazini.

Ludityanisiwe ifomu "atorvastatin"

Xa Elungiselela "Atorvastatin" ixabiso (testimonials isigulane ukuqinisekisa it) ifikeleleka ngokubanzi kwizigulane. It is a amayeza ekhuselekileyo kakhulu ukuba zinokudityaniswa kunye nezinye iindidi iziyobisi. Amaninzi, "atorvastatin" kunye nezinye statins ziveliswa bodwa, oko kukuthi, efonini mnye omnye kuphela isithako esebenzayo. Noko ke, kukho iindlela idityanisiwe.

Imizekelo iquka amachiza zilandelayo: "Kaduet", "Duplekor", "statins". Apha, "atorvastatin" kudityaniswe amlodipine, a blocker calcium channel, nesetyenziswa rhoqo kwi unyango ukuphazamiseka inhliziyo. Le umthamo ichiza unyule ugqirha.

Standard oyidlayo "atorvastatin"

Drug "Atorvastatin", izalathisi, iimbekiselo kunye neengcebiso malunga nokusetyenziswa bezonyango esinokucinga ngayo ngokutsha wethu, ifumaneka iidosi ezintathu eqhelekileyo: 10, 40 no-20 mg. A ukulungiselela edityanisiweyo "Kaduet" iqulethe 10 mg atorvastatin kunye amlodipine 5. "Statins" evela iintlobo ezimbini: 10/5 no-10 / 10mg. Xa Elungiselela "Duplekor" 4 umthamo atorvastatin kunye amlodipine: 10/5, 10/10, 20/5, 20/10 mg. Oku kunciphisa inani iipilisi ukuba izigulane kufuneka ukuba basebenzise kunye statins kunye blocker calcium channel yonyango izifo. Oku kuphunyezwe kwaye ukuhla iindleko zonyango.

Ukukhetha unique "atorvastatin"

iindlela zokuqala eziquka atorvastatin ebanjwe ekuthengisweni yi "Lipitor". Le nto ke amayeza yokuqala, leyo kuthwalelwa phandle umntu iimvavanyo. Kamva kukho nezinye iziyobisi phantsi kwezinye amagama. Kuba yobhaliso efunekayo ingqinisekiso olusesikweni kuphela bioequivalence "Lipitor." Okwangoku, oko ndoqhayisa a abenzi ezimbalwa. Ngoko ke, ukufumana kagqirha likagqirha ukuba ichiza ekhoyo "Atorvastatin" analogue yezi reviews kufuneka ifundwe ngenyameko.

Ngokufuthi, ugqirha lithethelela ukuba ichiza ukuba abe ngumntu obonakalise bioequivalence "Lipitor" yaye babe isiphumo ochazwe imiyalelo apha. Ixabiso "Lipitor" ifumaneka, akukho nzima ukufumana ibe izimuncumuncu. Noko ke, oko ungamiselwanga ukuba izigulane kunye nezibonelelo ezikhoyo ngenxa yokukhubazeka sifo eqhelekileyo. Kulo mzekelo, ezo amayeza ukuze imiselwe ilawulwa concessional yi-Centre for iimviwo neemvavanyo amayeza. ukusebenza lwabo nayo yaba.

Baqinisekiswa malunga "atorvastatin"

Kwi yokulungiselela "Atorvastatin" ngokutsha nasiphi na isigulane ayikwazi afaneleke, kuba ngaphandle nokuhlola inkangeleko lipid akwenzeki kuligweba imiphumo iziyobisi. Ngoko ke, ukuze kuqinisekiswe ukusebenza, kufuneka sihlalutye utshintsho amaqhekeza lipid. Ngaphezu koko, nayiphi "Atorvastatin", izimvo zazo zifumaneka ezininzi, inika ingcaciso ngayo ezibi. Avamise kakhulu iziphumo umzimba. Zinetyhefu lisezantsi yaye ngokufuthi imperceptible. Noko ke, kulo naliphi na ityala imbonakalo cytolysis syndrome kunye transaminases ukwanda ezintathu kufuna ukususwa beziyobisi.

Izigulane bathi iziphumo zinetyhefu zinqabile. Ngenxa yesi sizathu, izigulane ezininzi acetyiswa kwabandaziyo iziyobisi okanye izalamane, nangona indawo efunekayo thethwano lonyango, uvavanyo lomngcipheko kunye nokuzimisela amaqhezu lipids igazi. Ukongezelela, abaninzi isiyobisi engasekhoyo iipropati eyabelwe, umzekelo, ukuba uyakwazi ukwehlisa ubunzima bomzimba.

Kodwa sihlolisise imfuneko yokuba kakhulu "Atorvastatin" ncomo iziyobisi. Elwe akukho ezifanelekileyo, kwaye kwenziwa kuphela ngokusebenzisana imithwalo kunye nokudla. Ludityanisiwe ukusetyenziswa "atorvastatin" kunye nezinye arhente lipid-yandisa, njengoko kudla kucetyiswa ukuba abantu ngaphandle uqeqesho zonyango, kukhokelela rhabdomyolysis zesibindi letyhefu.

Izimvo oogqirha malunga ichiza

Kwi yokulungiselela "Atorvastatin" ngokutsha ugqirha kubaluleke ngaphezu ngokutsha yesigulane. Kukwasebenza kwanjalo kwamanye amachiza. Ngokubanzi, i liphendla zonke Izicatshulwa iingcali agcwele ukhuseleko ichiza kunye nokusebenza. Oku kunciphisa cholesterol iyonke kunye LDL, ngelixa sisenyusa HDL. Oku kubaluleke kakhulu kuba kuvumela ukuba ukulawula ukukhula neplaque atherosclerotic, kwaye alulibazisayo uhlaselo iposi engabalulekanga.

Dynamics ukusebenza hypocholesterolemic kumalungiselelo "Atorvastatin" (a ngokutsha phantse wonke ugqirha iyakuqinisekisa oko) kubonisa kakhulu. Kuqheleke profile serum lipid lufezekiswa ngaphakathi kweenyanga 1.5-2. I 'rosuvastatin "kuyafikelelwa kwiintsuku ne30-50. Nangona kunjalo, lo gama i "atorvastatin" izifundo ezininzi clinical ukuxhasa ukusebenza kunye nokhuseleko. Ngokubanzi, aba ezimbini zeziyobisi elungileyo, iyileyo ezinokusetyenziselwa ukunyanga hypercholesterolemia kunye prophylaxis izifo zentliziyo.

Neendleko zamayeza

Ichiza "Atorvastatin" ixabiso (iirivyu ezininzi ngale svidelstvo) ezahlukileyo ngokuxhomekeke umenzi. Ezibiza kakhulu i "Lipitor" - siyobisi sokuqala. indleko yonyango Inyanga ngu 900-1100 engange xa efumana umthamo we-40 mg. Xa idosi yemihla ngemihla ye-20 mg iindleko unyango 800-900 engange. Generic "Lipitor" abiza kakhulu.

Iindleko zonyango kunye ngenyanga "Atoris 40 mg" engange-500, ngoxa kokufumana 20 mg - 200 engange. I "Atoris" - into bioequivalent "Lipitor" iziyobisi, ngokubuyisela ngokupheleleyo. Kukho kwakhona iziyobisi atshiphu, "Torvakard" "Lipitor", "Torvas" iindleko zonyango ngenyanga idosi yemihla ngemihla ye-40 mg ukuya engange 300 enganeno. Kwaye ke ixabiso unyango kunye idosi yemihla ngemihla mg 20 liya kuba 100-150 engange.