Peptides elifutshane polypeptides njengenxalenye ngesondlo imidlalo. Yintoni ukukhetha?

Peptides ziyindlela ethandwayo esetyenziswa kwiinkqubo ekulungiseleleni ngesondlo zemidlalo kweembaleki kwezemidlalo engahlawulwayo nobungcali [3]. Zonke peptides - ezemidlalo components zesondlo - zingahlulwa zibe ngamaqela-2: peptides ezimfutshane (ezincinci) kunye polypeptides ( "khulu"). Le peptides iqanjwa components ezilula - acid. Ukuba peptide equlathe inani elincinane asidi acid, umzekelo-3 okanye ezi-4, - yinto peptide elifutshane. Ukuba peptide yi 20-30 acid, kwaye ngaphezulu - yinto polypeptide. Polypeptides - oku phantse iyafana naleyo iiprotheni - iimolekyuli ezingundoqo emzimbeni wethu. Kutheni kubalulekile ukuba ukwahlulwa ibe peptides ezifutshane polypeptides? Ukususela Ubude peptide kuxhomekeke ukuba umsebenzi wayo, ukusebenza kunye nokhuseleko xa esetyenziswa ekondlweni kwezemidlalo.

Okwangoku popular njengomdlalo amacandelo zesondlo zizinto polypeptides ezikhuthaza umtshiso amanqatha, ukwandisa ubunzima kwezihlunu, ukwandisa sifo, ukuphucula impilo jikelele. Noko ke, kuneengxaki ezibalulekileyo. Polypeptides, ingakumbi iihomoni peptide, babe zingaphawulwa kwezinye, ukuphazamisa iihomoni zendalo emzimbeni. Ukongeza, onke peptides 'enkulu leyo "bezingaqhelekanga emzimbeni kwaye baxabane nomzimba. umsebenzi High komzimba oluvavanya rhoqo womdlali, badla negalelo yokuncipha kwenani sifo, nto leyo eyandisa phambili kwicala kukwalisa ekusebenziseni polypeptides. Ekubeni polypeptides zidla ingadibani ephilayo isilwanyana [2, 3, 9], nokunyhashwa technology zokucoca zingaqulatha ubumdaka yingozi - iiproteni amazwe, amaqhekeza DNA, iintsholongwane, prions, nayo leyo ilifa immunogenicity (ukukwazi eyenza engavumelani) kwaye kukhokelela kuphuhliso izifo.

Ngaba unako ukwenza njalo, ukuba ugcine iimpawu osebenziseke polypeptides bioregulatory kwaye ngaxeshanye ukususa iimpazamo zabo? Ewe, ngoku sele ube kunokwenzeka. Ngenxa yophando olwenziwe iminyaka, kwafunyaniswa ukuba polypeptide ngasinye neziko esebenzayo - ukuba yinxalenye encinane kuyo, nenoxanduva umsebenzi lo peptide. Ngokusekelwe kuhlalutyo ukubunjwa polypeptides ngokutsho iteknoloji ekhethekileyo sele yenziwe Ideal Pharma GmbH peptides ezimfutshane, equka 2, 3 okanye 4 iintsalela acid acid [5, 6, 7]. peptides elingephi akuyomfuneko lokwenza ikheswa kwinyama isilwanyana, kwaye kuhlanganiswa afana. Ikhuseleke ngokuba peptides zokwenziwa musa eziqulathe izithako ezibangela komzimba. Ngoko peptides Iph emfutshane isakhiwo efana ngokupheleleyo esebenzayo (ezisebenzayo) polypeptide iimolekyuli kumaziko endalo yaye alubonwanga yi umzimba njengoko kwamagciwane. Kubalulekile ukuqaphela ukuba peptides ezimfutshane Iph, ukuba ungaphinda "umsebenzi" ye zinemoletyhule polypeptide esetyenziswa ekondlweni kwezemidlalo kumanqanaba aphantsi kakhulu "peptides enkulu."

Enye inzuzo ebalulekileyo Iph peptides elifutshane ukukwazi kwabo ako ngcono ngumzimba xa kuthelekiswa polypeptides. Yenzeka njani le nto? Iiproteni kunye polypeptides engena umzimba ngokutya, faka esiswini kunye emathunjini. Apho ke ngoncedo enqanda ezizodwa (peptidases) "kunqunyulwa" zibe ngamaqhekeza amancinci - peptides mfutshane eziquka iintsalela acid acid-2 okanye ezi-3. Ke peptides ezimfutshane ngenisa igazi naxa uthuthwa kwizihlunu kunye namanye amalungu kunye namalaphu, nto leyo ibe nefuthe elawulayo. Uninzi polypeptides, apho sifumana njengenxalenye ngesondlo imidlalo ziya kuba "kunqunyulwa" peptidase kwaye ayiyi kuba nefuthe elifunekayo, okanye umphumo uya kuba buthathaka. Kule short peptides Iph bayinxalenye ngesondlo lezemidlalo ngoko nangoko ukusuka esiswini namathumbu ngenisa egazini kunye namalaphu, ngaphandle ngokwaphula. Okwangoku Ideal Pharma GmbH kuqingqa, kuhlanganiswa uthotho peptides ezimfutshane, ekuthiwa Iph, kuba zamayeza, ukutya, ukulungisa kunye imidlalo mveliso, nto leyo enza abanamajoni omzimba, luvo yonyango, kufuneka iipropati antioxidant, sebenzisa ukutya kukhonza okuthintela umhlaza kunye ukwanda abantu babephila [5, 6, 7, 8]. Kufuneka kuqatshelwe ukuba polypeptides azisoloko ukwazi indlela ngqo komsebenzi eziphilayo, ngoxa peptides ezimfutshane Iph Ezo izifundo ubambe lula kakhulu kwaye singakwazi ukuya yemfuza umkhondo indlela yonke amanyathelo peptide [1, 5, 6, 7, 8, 10 ]. Oku kukuvumela ukuba ukulungiselela ngokuzithemba ukuba ukusebenza kunye nokhuseleko peptides ezimfutshane Iph eveliswe yi Ideal Pharma GmbH (Germany).

Ngoko ke, peptides ezimfutshane Iph, ukuba zonke iziphumo ngokobugcisa polypeptides, ekhuselekileyo, non-immunogenic, yiba mechanism inzululwazi-based yezenzo kwaye simse njengenxalenye ngesondlo ezemidlalo [4] kunye kumda wesangqa yophuhliso Pharmacology mihla kunye namayeza eziphilayo.

Imithombo ukuqinisekisa ukusebenza kunye nokhuseleko peptides ezimfutshane

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