"Theophylline": imiyalelo ukusetyenziswa. "Theophylline": ezibonisa ukuba ukusetyenziswa analogue

Ukuba umntu unesifo ngokuma isithintelo, oku kubonisa ubukho bezifo obstructive sifo pulmonary (COPD). Esi sifo yinto eqhelekileyo. Ngokufuthi, ukwenzeka kwale sifo sibonakala iintshayi. Uphuhliso kwesi sifo sibangelwa isifo hit, okanye into ethile umonakalo semiphunga. Umntu ngokuma constriction abakwazi uwukhuphe. Ngenxa yoko, iimpawu eziphambili zizinto ezibonisa dyspnea sifo, ukukhohlela, kunye nemveliso yesikhohlela. Kubalulekile ukwazi. Avamise kakhulu uphuhliso kweentlobo ezithile COPD. Le lubandakanywe nezenzo isifuba, iphika esinganyangekiyo, emphysema, bronchiectasis. Xa unyango ezi kunye nezinye izifo kuya kunceda ezifana ichiza njenge "Theophylline". Imiyalelo zokusetyenziswa ichiza ziya kuhlawulwa kwesi sicatshulwa. Iinkcukacha ezingaphezulu malunga noku.

incazelo

"Theophylline", ogama ukwakheka ziza kuchazwa ngezantsi, i ngumgubo crystalline emhlophe. Kuyinto ezinyibilikayo kancinane emanzini abandayo (kwi ratio 1: 180), kodwa ngokulula unyityilikiswa emanzini ashushu (in a umlinganiselo ka 1:85). Kwakhona esixutywe alkalis kunye asidi.

isakhiwo

Kulo ekuqulunqeni eyona nto iphambili esebenzayo i theophylline. apha zikwaquka amacandelo athile abangabancedani. Ezizezi - monohydrate lactose, nemagnesium stearate, talc, methacrylic acid.

release Form

Kukho iintlobo ezininzi kule nkalo. "Theophylline" ziveliswe njengoko macwecwe zisekelwa-ukukhululwa (0.1 g, 0.25 g), njengezingxobo (0.125 g, 0.5 g), kunye suppositories (0.2 g).

izenzo kwemithi

Ukusebenza kuqulunqo bathi inobuxhaka- xhaka. "Theophylline", izimvo zazo ezintle, ukuphumla usebenzisa izihlunu bronchi, kukho umdla vasodilator amanyathelo. Le ukulungiselela kuqinisekisa ukusebenza okuqhelekileyo iziko sokuphefumla. Ukuphelisa intlungu uvalo kunye nokuphucula ukusebenza izihlunu intercostal nayo inegalelo "Theophylline". ukusetyenziswa kwayo inkqubo rhoqo kunciphisa amathuba okubonakalisa ziyabagulisa le nokuphefumla uhlobo inkqubo imizimba. Uthe amalungiselelo Lingaba isiphumo umchamo. Ubukho izinto ezisebenzayo kwi medicament ikhuthaza kuqheleke umsebenzi yokuphefumla, ukunciphisa izinga carbon dioxide kunye umoya zanda. "Theophylline" ngempumelelo kwandisa kwegazi sentliziyo. Kwakhona inceda ukwehlisa umoya okanye ubunzulu iimpahla ingqondo, izintso nentliziyo. Xa wenza unyango elide iyanda iphecana biliary, ukuzinza microcirculation kunye nokumelana erythrocyte ukuya ukunyuswa deformation. Xa izigulane abaphethwe hypotension, ukuze ukwehlisa uxinzelelo lwegazi. Ukusetyenziswa lokufumana amalungiselelo afana "theophylline", kunye beta-blocker, kunye ntsholongwane ikhokelela nengozi eyonyukileyo yeziphumo ebezingalindelekanga.

Ubungqina obubonakalayo buxela

Nikezela uthe amachiza isahlakalo inyumoniya sombefu, abanesifuba iwonga, iphika obstructive, emphysema miphungeni. Kwakhona asisetyenziswa nje ngoncedo ezisanda kuzalwa kunye umoya. Sebenzisa 'Theophylline "ngokuyintloko nje bronchodilator. Kwakhona, ungayisebenzisa njengendlela cardiotonic eliphakathi (kwandisa ngamandla izishunqulelo ngentliziyo) kunye umchamo (umchamo) kweziyobisi ngenxa ekubonakalisweni congestive of imvelaphi kwezintso kunye inhliziyo. Maxa wambi iphethwe kunye nezinye ukudumba kunye bronchodilators.

Inkcazelo eneenkcukacha ezininzi of kuqulunqo uthe

Ekuqaleni, xa unyango COPD yi bronchodilators sabelo. Bathwala yomoya zokudiza. Enye yezi iziyobisi, njengokuba sele kukhankanyiwe apha ngentla, ukulungiselela loo njenge "theophylline". Imiyalelo zokusetyenziswa luphawu njengendawo ichiza bronchodilator, leyo uwugcinayo ekuthiwa-uvimba of receptor purine. Ubukho balo matshinana impembelelo i kuqinisekisa ukususwa inkantsi kwi esihlunwini kakuhle bronchi, ekupheliseni intlungu uvalo, ubulunga ioksijini emiphungeni, ukuphucula umsebenzi izihlunu intercostal. Ngenxa yoko, yomoya uvule, umntu ukuphefumla lula.

Kuye ngcono, "Theophylline". Imiyalelo yokusebenzisa ibonisa ukuba eli chiza nga ngokuqinisekileyo nefuthe kungekuphela iphecana yokuphefumla, kodwa ezinye iinkqubo zomzimba. Eli chiza kunceda ukwandisa iimpahla yegazi nemithambo kunye peripheral kuphazamisa inkqubo zegazi adhesion, ngaba isenzo wobulali umchamo. Inika nqgo umsebenzi nokuthenwa intliziyo izihlunu (myocardium), uxinzelelo lwegazi asezantsi, kwakunye nefuthe kuyingenelo kwisistim luvo. Ngenxa yoko, ichiza uyakwazi ukwenza ubhetyebhetye, ngaxeshanye ukuba antiasthmatic, bronchodilator, umchamo, spasmolytic, vasodilatory kunye neempawu cardiotonic.

"Theophylline": imiyalelo yokusebenzisa

Ukuze ubone oyidlayo, kukho imiqathango ezininzi. "Theophylline", ngokwemiyalelo, kufuneka uthathe abantwana abaneminyaka eli-14 kunye nabantu abadala, 300 mg ngosuku izihlandlo 2-3. Kulo mzekelo, iyeza kufuneka basele amanzi kukuninzi. Ukuba kuyimfuneko, ithamo angandiswa ku 500 mg amaxesha 2 ngemini, xa kucetyiswa ngugqirha wakho. Ukuba isigulana enobunzima nomzimba ngaphantsi kwama-60 kg, idosi kufuneka ibe li-100 mg 2 amaxesha ngemini. Kulo mzekelo, i amisiweyo kusasa nangokuhlwa yokwamkela le alungiselelwe "Theophylline". Umyalelo ithi unyango kuyimfuneko ukuqala ngeedosi ezincinane ngokuthe ngcembe kwandisa ukuba ibe. Eli chiza kufuneka kuqhutywa ngokuthe rhoqo. Kufuneka iintsuku 2-3. Ngokutsho lo myalelo, ukuba inkqubo yonyango kuyimfuneko ukuqhuba iinkqubo rhoqo diagnostic. Ezizezi - ukuphunyezwa yegazi, imilinganiselo uxinzelelo lwegazi, X-ray, ECG, ukulinganisa izinga cholesterol kunye mpilo. Ukubonakalalisa isiphumo konwaywa uthe iindlela eliza emva kweentsuku ezimbini. Kubalulekile ukwazi. Xa yolwamkelo ehlanganyelwayo isiyobisi kunye antispasmodics kuye ukwandisa impumelelo yenkqubo yonyango. "Theophylline" kunciphisa sisenzo iziyobisi arhente antidiarrheal. Ithuba ukuphiliswa kufuneka balumke ekwenzeni naziphi iimveliso caffeine yokunciphisa.

Ukuthatha ichiza ngethuba lokukhulelwa nokuncancisa

"Theophylline" isiphumo ekukhuleni kosana olungekazalwa phantsi udidi "C" yi FDA. Isixhobo ingena isithintelo placental. abasetyhini abakhulelweyo kunokuthiwa iziyobisi kuphela kwiimeko apho inzuzo kulindeleke ukuba unina mkhulu ingozi olungekazalwa. Kweli xesha ndiya ezintathu neeveki zokugqibela zokumitha kufuneka uthathe iziyobisi, ukugcina zikhombisa engqongqo. Kubalulekile ukukhumbula.

Of kokuma amaninzi lubonisa ukuba kugqitywe theophylline ngexesha ezintathu III zokukhulelwa lifinyele. Oku kufuna ukuba bazimisele lwaqho xi ukwimo egazini kunye nokuncitshiswa idosi kunokwenzeka.

Ibele "Theophylline" oluwe ubisi kwaye kunokubangela iimpawu ucaphuka kwiintsana okanye neminye imiqondiso yetyhefu. Kubalulekile ukwazi. Uyondelelwano lwee- into athi ngobisi lwebele malunga elilingana ikhontenti yayo egazini serum ngayo nonina. Kwakhona, oku kuthetha ngokubonakalayo abangaphangeliyo kwamathumbu zesibeleko.

Izimo

"Theophylline" imiyalelo zokusetyenziswa njengoko kuchaziwe apha ngasentla, ukuba contraindicated xa kukho:

• Isici.
• Hyperthyroidism.
• iqhosha Acute engabalulekanga.
• stenosis Subaortic. Esi sisifo non-yokukrala ventricle lasekhohlo inyama yentliziyo kwezihlunu. Lubonakala yi ukubonakaliswa exineneyo kabukhali kwisisu yayo.
• Arrythmia.
• Sokuwa kunye nezinye iimeko convulsive.
• Ukukhulelwa.

Ngenyameko kuyimfuneko ukwenza ukwamkela ichiza ngexesha ngokubonakala isifo okwenziwa sisilonda sikabhobhosi esiswini kunye duodenum.

imiqathango ethile

Ukutshaya luchaphazela kakhulu Ukubanjwa ukutya kunye kukhuthaza kwezinto ezifana ezifana theophylline. Kufuneka kukhunjulwe. Abantu yaba ngumsi yonke imiqulu 1-2 yecuba ngosuku, abe nokuphungulwa ixesha isiqingatha-ebomini. Xa izigulane hepatic, ukusilela senhliziyo okanye zokuphefumla ngayo, kwakunye izifo ezosulelayo nokushisa kwenzeka deceleration Ukungabikho into esebenzayo. Reception kotywala caffeine-uhlobo iimveliso une anefuthe elivakalayo nethe of theophylline.

intsebenziswano

Ichiza "Theophylline" ikhuthaza isiphumo potentiation of β2-agonists. Kwakhona kunokusenza lafa, nto leyo ibangelwa uhlobo isiyobisi sympathomimetic kwaye uyakwazi zinqanda inkqubo ukufunxeka phenytoin. kubulawe Slow ye indlela yenzeka intsebenziswano yawo kunye 'erythromycin "yaye" phenobarbital. " Lithetha "Theophylline" inikeza ukwanda zinomgutyulo sezintso lwe Lithium. Kulo mzekelo, intsalela therapeutic aphazanyiswa kwizigulane abo ukuthatha iityuwa esihambelanayo. Ichiza "cimetidine" igalelo ingqalelo amanqanaba theophylline igazi, kwaye yandisa ixesha zokurhoxa layo. Amayeza kunye neziphumo ezifanayo ziya zidweliswe ngezantsi.

Ubukho of yeziphumo ebezingalindelekanga

Xa ufumana amachiza athi ukuze iimpawu ezahlukeneyo ezimbi. ezizezi:

• Kungahle iimpawu nesiyezi, sokulibala, intloko ebuhlungu, niphele, ixhala, lafa, ukudideka, ukuxhuzula.
• Xa inkqubo yemithambo - arrhythmia, tachycardia, angina lobuxoki, ukuncipha ngesiquphe uxinzelelo lwegazi, sifuba angina.
• Kwinkqubo yokwetyisa - ukuvela isicaphucaphu, ukugabha, heartburn, urhudo, flatulence, ukudumba, gastritis.
• Xa umsebenzi so indlela reception ibonakala ezinye kubonakaliswa ziyabagulisa ngohlobo sokudlathuka kweenwele, ukutsha, urticaria, dermatitis, ifiva, ukubila nolusu irhashalala.

libanda

Kulo mzekelo, kukho iimpawu ezithile. Phantsi kwezi mpawu zibandakanya:

- yokususa;

- isiphithiphithi;

- yombono;

- tachycardia;

- arrhythmia;

- hypotension;

- isicaphucaphu;

- isisu;

- ukugabha kunye admixture igazi;

- hyperglycemia;

- lactic metabolic.

Xa ezi mpawu unikwe unyango ethile. Oko kukuthi, olwenziwe ngu:

• indlela wamalahle yasebenza.
• kummandla Irrigation wamathumbu indibanisela neetyuwa nesisombululo polyethylene ethers.
• ukwamkelwa efakwa "MCP" okanye "Ondansetron" iimpawu ziphawulwe of isicaphucaphu nokugabha.
• Reception "benzodiazepines", "Phenobarbital" (okanye sodium thiopental) kunye relaxants kwezihlunu neuropathy kwi isenzeko ukuxhuzula.

"Theophylline": nabalingani

Kukho iziyobisi ezininzi ezahlukeneyo kolu hlobo. Kulo mzekelo, cinga amayeza zilandelayo:

- "Teobiolong" ( "Theobilongum").

- "Spofillinretard" "(Spophillin kunamandla").

- "Perfillon" ( "PerphyUon").

- "Neoefrodal" ( "Neo-Efrodal").

- "Franol" ( "Franol").

indawo yokubeka

Le amakha and tablets ( "theophylline") sigcinwe, kwindawo eyomileyo nemnyama. Zabo ezikhabhathini yiminyaka emihlanu. amakhandlela Ukugcinwa kufuneka kwenziwe efrijini. Ngelo xesha linye akufunekanga emkhenkceni. Yabo kwi-ubomi iminyaka emine.

ngenxa

Emva kokufunda ngasentla, umntu unokucinga ukuba yintoni isiyobisi ezifana "theophylline", ixabiso owamkelekileyo (ngaphakathi 70-160 miri.). Kwakhona kule ndinyana waxelela malunga imiyalelo ukusetyenziswa kweziyobisi kunye nentsebenziswano yawo kunye nezinye iindlela.