Ukulungiselela "i-Pentas": imiyalelo yokusetyenziswa, iifanekiso kunye nokuhlaziywa

Ngumphi umthamo abayalela amachiza e-Pentasa? Izikhokelo zokusetyenziswa, ukuphononongwa kunye nokuqulunqwa kweziyobisi zixutyushwa ngezantsi. Kwakhona kwizinto eziphathekayo kwinqaku le ngcaciso malunga neendlela zokukhululwa kwale mayeza kunye neempahla zayo.

Ukubunjwa, iifom zonyango

Kukho iindlela ezininzi zokukhululwa kweziyobisi. Khawucinge nje ngoku.

Isilwanyana "Pentasa" - amaphilisi (500 mg, 100 mg) inyathelo elide. Zimhlophe nge-gray tinge, kwaye nazo zinamabala amaninzi ezimnyama, imilo ejikelezayo rhoqo, enobungozi, i-facet kunye nemibhalo ebhaliweyo kumacala omabini.

Icandelo elisebenzayo lale mziyo yi-mesalazine. Kwakhona kubandakanywa ukubunjwa ngamayeza angasebenziyo ngendlela ye-povidone, i-ethylcellulose, i-stearate ye-magnesium, i-talc kunye ne-microcrystalline cellulose.

Xa kuthengiswa kweziyobisi "Pentasa" (amacwecwe), isithunzi esichazwe kwinqaku, siza kwi-blisters, ezipakethe zekhadibhodi.

Kufuneka kwakhona kuqatshelwe ukuba imithi enombuzo ingathengwa ngohlobo lwe-suppositories, i-granules ekhutshwayo kunye nokumiswa kwemihlathi.

I-Pharmacology yemveliso yeyeza

Iyiphi imishanguzo yePentasa? Umyalelo wokusetyenziswa uthi le ngxube inefuthe elichasayo kwaye lisetyenziselwa ukuphatha isifo seNNC nesifo sikaCrohn.

Iipropati ezichasayo zezi ziza zibonakaliswa kuphela kunye nokusetyenziswa kwendawo. Esi siphumo siphumo ngenxa yokuqulunqwa kwama-leukotrienes kunye ne-prostaglandins, kunye nokuvinjelwa kwemisebenzi ye-lipoxygenase (neutrophilic). Ukongeza, le nkunkuma iyakwazi ukunciphisa ukugcinwa kwe-immunoglobulins kunye ne-lymphocytes kwaye inqande i-degranulation, ukufuduka kunye ne-phagocytosis ye-neutrophils.

Iimpawu zesisu

Iipilisi zePentasa (amacwecwe), ukubunjwa kwawo okwenziwe ngasentla, kubonisa umsebenzi ochasene ne-antibacterial kunye ne-cocci kunye ne-Escherichia coli. Ibuye ibe nefuthe lokulwa ne-antioxidant ngenxa yekhono lomsebenzi osebenzayo ukubopha ukukhulula ama-radicals (oksijini) kunye nokuwachitha.

Ukusetyenziswa okufanelekileyo kweli arhente kunciphisa kakhulu umngcipheko wokuphindaphinda kwisifo sikaCrohn, kubandakanywa nabantu abane-leitis (ixesha elide lesi sifo).

Inqobo yesenzo sonyango

Iipilisi zePentasa zisebenza njani? Imiyalelo yokusetyenziswa ibonisa ukuba iziphumo zonyango le nkunkuma zibonakalisa ngokukhawuleza emva kokuqhagamshelana kwendawo ye-mesalazine kunye ne-intestinal mucosa.

Emva kokuthatha izidakamizwa zomlomo, ithebhulethi ngokukhawuleza iyancipha ibe ngama-microgranules asebenza njengeefom ezahlukileyo kwaye ikhulule i-substance esebenzayo, i-mesalazine, ngokukhawuleza. Oku kuqinisekisa ukuphumelela kwamachiza ngaphezulu kwe-12-finger kwi-rectum nayiphi na i-pH.

Pharmacokinetics ye-arhente

Ukuthathwa kwamachiza e-Pentasa njani? Imiyalelo yokusetyenziswa ikwazisa ukuba i-microgranules yeepilisi ezilahla zifikelela kwi-duodenum ngethuba lemizuzu yokuqala engama-60.

Phantse 30-50% yesilinganiso esithathiweyo sithathwa emathunjini amancinci. Ukuxhamla kwe-mesalazine kunye neeplasma zamaprotheni ngama-43%, kunye ne-acids N-acetyl-five-aminosicicylic - 73-85%.

I-Mesalazine, kunye neziphumo zayo azingena kwi-BBB. Iipropati eziqulathekileyo zesilwanyana zibonakaliswe kuphela xa usebenzisa i-dosage ephezulu (malunga ne-1500 mg ngosuku).

I-acetylation yama-mesalazine ibonakala kwi-mucosa yamathumbu kunye nesibindi. Le nkunkuma igxothwe emcinini, ubisi lomama kunye nemfesi.

Imiqondiso yokusetyenziswa kweyeza

Ziziphi iimeko apho inkunkuma "i-Pentas" (iipilisi) iboniswa? Iimpendulo zeengcali zithi le nyilisi ibonakaliswe kakuhle xa:

• I-colontic ulcerative colitis;
• Isifo sikaCrohn.

Imiqathango yokusetyenziswa kwemveliso yeyeza

Ngaphantsi kweemeko ezingenako ukusebenzisa isixhobo esinjalo njenge "Pentasa"? Imiyalelo (amacwecwe kunye nezinye iifom zezilwanyana zinokuphikisana okufanayo) zithetha ngezi zinto ezilandelayo:

• Diathesis inzima;
• Izifo zegazi;
• Ixesha lokubamba;
• Ulcer yephepha lokutya;
• Iiveki zokugqibela ezi-2-5 zokukhulelwa;
• Ukungabi ne-glucose-6-phosphate dehydrogenase;
• Kudala ukuya kwiminyaka emibini;
• Ukuhluleka kwe-Renal kunzima;
• Ukunyanzeliswa kwemvelo kwizinto zendalo;
• Ukuhluleka kweHepatic kunzima.

Ngokunyamekela okhethekileyo, isilwanyana kufuneka sisetyenziswe kwi-trimester yokuqala yokukhulelwa, kunye nokungaqiniseki kwe-hepatic ne-renal.

I-Pentasa amayeza: imiyalelo yokusetyenziswa

Ukukhethwa kwendlela yokulinganisa kwesi sidakamizwa kuxhomekeke ekuhlaleni kwenkqubo ephambili ye-pathological, kunye nobukhulu bomlenze wamathumbu.

Iifomati ze "Pentas" kunye nokumiswa kwazo zichazwe kwiifom ze-distal zesifo (proctosigmoiditis). Kule meko, ikhandlela zisetyenziswe kathathu ngosuku nge-500 mg.

Ukulungiswa komlomo kwePentasa (iipilisi) kumiselwe njani? Imiyalelo yokusetyenziswa ithi lolu hlobo lonyango lunconywa ukuba lisetyenziswe kuphela kwiifom eziqhelekileyo zezifo. Ukuthintela ukuphindaphinda kwesifo sikaCrohn, amayeza asetyenziswa kane emva kwemini (1 g yemalazine). Ngokubhekiselele ekuthinteleni ukubuyiswa kwakhona kweNNC, kulo mzekelo, isicatshulwa simiselwe kathathu ngosuku ngemitha 500.

Xa isifo sidabukisayo, ikhosi yeyeza kufuneka ihlale kwiiveki ezi-8 ukuya ku-12. Kule meko, u-400-800 mg wamachiza kufuneka athathwe rhoqo imihla (kathathu ngosuku).

Kwiimeko ezinzima, ukwanda kwimihla ngemihla ukuya kwi-3-4 gram kunokwenzeka.

Iipilisi "I-Pentas" kufuneka zithathwe ngokukhawuleza emva kokutya, ngaphandle kokuhlafuna nokuhlamba ngamanzi alula.

Imiphumo emibi

Kwezinye iimeko, izilwanyana ezibhekiselwe kumbuzo zibangela iziphumo ezilandelayo:

• I-Stomatitis, intshukumo yeengcipheko, umlomo owomileyo, utyumbe, isisonguluko, imizwa ecindezelekileyo;
• Ukunciphisa ukutya, ukuvakalelwa kwentliziyo ngokukhawuleza, ukuguquka kwentliziyo, ukuphefumula okufutshane kunye nomsebenzi wokwenyama, ukuhlanza;
• I-Hematuria, isifo sohudo, i-tachycardia, i-hepatitis, intlungu ephindaphindiweyo;
• Ukwandisa kwi-enzyme yesibindi, ukunyuka kweengcinezelo zegazi, i-pancreatitis, i-polyneuropathy;
• I-Crystalluria, tinnitus, proteinuria (i-protein secretion), i-migraine ikhanda;
• U-Oliguria, i-leukopenia, i-anuria (ukungabikho kwamanzi), i-thrombocytopenia, ukwakheka kwe- nephrotic syndrome ;
• I-Hypoprothrombinemia, i-agranulocytosis, i-eosinophilia, i-anemia.

Kufuneka kwakhona kuqatshelwe ukuba ngaphandle kwesiqhelo sokuthatha eli gulana kwisigulane kunokuqwalaselwa: i-oligospermia, i-alopecia, i-photosensitivity, ubuthathaka kwimida, i-lupus-like syndrome, iyancipha ukuveliswa kwemveliso yamanzi.

Ukugqithisa ngokwemveliso yomhlaza

Ukugqithiswa kwezidakamizwa ezicatshangelwayo kubonakaliswa ngokulala okukhulu, isisongela, i-gastralgia, ukuhlanza kunye nobuthathaka kuwo wonke umzimba. Ukuphelisa iimpawu ezinjalo kudinga ukuhlanjululwa kwesantya esifike ngexesha, kunye nokuqeshwa kwamathambo kunye nokuqhutywa kweyeza-post-syndrome.

Ukusebenzisana kwezidakamizwa

Iipilisi ze-Pentasa zinganciphisa umlinganiselo wokutsalwa kwe-cyanocobalamin. Kwakhona, i-mesalazine ithuthukisa ukusebenza kwee-agents zangasese (kuquka i-block blockers blockers).

Kufuneka kuphawulwe ukuba le nkunkuma ikwandisa ulcerogenicity of glucocorticosteroids, inobuthakathaka umphumo we rifampicin, inyuse isifo se-methotrexate kwaye inefuthe le-hypoglycemic kwi-derivatives ye-sulfonylureas, i-spironolactone, i-sulfonamide kunye ne-furosemide.

Ulwazi oluKhethekileyo

Ukuba ulahlekelwa umthamo we-mesalazine, kucetyiswa ukuba uyithathe kunye nezayo okanye kwikusasa elikufutshane. Ukuba kukho amanani amaninzi alahlekileyo, kufuneka uqhagamshelane nodokotela ngokukhawuleza. Ngelo xesha livunyelwe ukuyeka unyango ngokwakho.

Ngamanye amaxesha, malunga nemvelaphi yokusetyenziswa kwesilwanyana esikulo mbuzo, izigulane zigcinwa kumchamo womnxeba kunye neenlense zoqhagamshelwano kwi-hue e-yellow-orange.

Kwinkqubo yokonyango nge-mesalazine, ukulawula rhoqo unyango malunga nomsebenzi wesigulane somgulo kuyimfuneko. Kwakhona kuyimfuneko ukuba rhoqo uqhube i-urinalysis yesigulane kunye negazi lakhe (ngelixa lonyango, kwaye emva kokugqitywa kwayo).

Ubungakanani bokuba kwenzeka ngokungahambi kakuhle kwimiba yokuthatha le mayeza kunyuke kulabo "abakwi-acetylator".

Ngokuphuhliswa kwesifo esixakekileyo sokunganyamezeli kwisithako esisebenzayo, ukulungiswa kwe "Pentasa" kuhluthwe ngokukhawuleza.

Amayeza afanayo kunye nokuhlaziywa kwabathengi

Ngaba uyazi ukuba yintoni enye inokuthi ithathe indawo yonyango? Udokotela ophetheyo kufuneka akuxelele ngale nto. Njengomthetho, iziyobisi ezilandelayo zibhekwa njengezifana nale myeza: Mesakol, Salosinil, Salofalk, Mezavant, Mesalazin, Asakol.

Yintoni abathetha ngabathengi ngale ndawo? Ngokutsho kokuphonononga kwabo, eli liyeza lonyango elichanekileyo elinokuthengwa nakwephi na ikhemisi. Izigulane zibiza ukuba i-mesalazine ayilunganga kakhulu kuphela, kodwa ekukhuselweni kwesifo sikaCrohn, kunye nesifo se-ulcerative colitis.