Amakhandlela "Flex": isikhokelo, ncomo, amaxabiso, analogs

"Flex" Amakhandlela iqela zamachiza ze NSAIDs (non-steroidal anti-ukudumba agents). It has anti-ukudumba, antipyretic, iintlungu kunye antiagregatsionnoe senzo. Thaca iibhloko zeziyobisi umsebenzi enzyme (cyclooxygenases 1 no-2) kunye prostaglandin yokuqaphela. Le nkqubo ithintela ukuyilwa yabalamli ukudumba kwaye abangaphangeliyo imbonakalo leukotrienes.

Amakhandlela "flex" antibradikininovuyu umsebenzi umboniso, lagxila lysosomal biomembrane, unobangela inhibition umsebenzi neutrophil kubaguli unesifo "isifo samathambo". Anqanda zegazi ukulinganiswa. Isiphumo iintlungu kungenxa zombini iindlela esembindini neuropathy. Oogqirha abaninzi ukukhululeka intlungu kunye nonyango samathambo emiselweyo "Flex" (amakhandlela). Ixabiso ichiza yenza kube lula ukufumana ukuba iindidi ezahlukeneyo zezigulane. Izimvo medicament ndiyangqina kucikizeko yalo phezulu kunye nokhuseleko nempilo ngokuhambelana kunye neengcebiso.

Imiyalelo zokusetyenziswa ichiza ngokufanelekileyo elula, kunye nohlaziyo ukuqinisekisa ifuthe ngokucacileyo nezinyangayo. Inxalenye ichiza? Ziziphi iimpawu it anazo? Ingaba kukho naziphi na iziphumo ebezingalindelekanga eziyingozi? Iimpendulo zale mibuzo bakhangela izigulane ezininzi.

Khemikhali Ukubunjwa ichiza

Amalungiselelo imbaxa kwezinto bioactive kunye excipients:

• Ketoprofen (esisiseko ezimbaxa bioactive);
• fini;
• hydrogenated oli yemifuno;
• colloidal electronic dioxide;
• sodium ethyl parahydroxybenzoate;
• sorbitol;
• gelatin;
• oli yemifuno;
• glycerol;
• soy lecithin;
• titanium dioxide;
• sodium propyl parahydroxybenzoate.

"Flex" analogue namakhandlela

Xa oogqirha practice enyangayo kunokuba ngokukhutheleyo usebenzisa analogue le kuqulunqo ngasentla:

• "Artrozilen".
• "Ketonal Duo".
• "Artrum".
• "Bystrumgel".
• "Valusal".
• "Bystrumkaps".
• "Ketonal".
• "Oruvel".
• "Febrofit".
• "Flamaks".
• "Profenid".
• "Ketonal uno".

iinzuzo beziyobisi

Inzuzo ephambili ichiza kufuneka iquke ezi indices zilandelayo:

• nomphumela therapeutic eliphezulu;
• bioavailability eliphezulu ichiza kuthelekiswa kunye noontanga bayo.

lobubi iziyobisi

Kubakho iingxaki eziphambili "Flex" kufuneka siquke ezi khrayitheriya zilandelayo:

• ixabiso eliphezulu ichiza kuthelekiswa kubalingane;
• ayifumaneki yonke imihla (ixesha elide) Iifomu ukukhululwa.

Pharmacokinetics

Bondability izinto bioactive kweziyobisi kunye iiproteni plasma igazi 99 ekhulwini. Amakhandlela "flex" luphawulwa bioavailability aphezulu (90%). yoxinaniso therapeutic "Flex" egazini igcinwe iiyure ezi-6. Main cleavage pathways iziyobisi kwenzeka xa hepatocytes yi glyukorirovaniya. Isiqingatha-ubomi malunga neeyure ezimbini. Ichiza na cumulated, lithatyathwe becala izintso kunye nge amathumbu.

"Flex" (ikhandlela): imiyalelo, ixabiso

Le medicament ngasentla imiboniso emininzi ebanzi amanyathelo zonyango. amakhandlela "flex" adla kuchaziwe practice lwezonyango ukuba unyango intlungu abasabela yokukrala imvelaphi ezahlukeneyo. Ukusetyenziswa amayeza kucetyiswa ukuba ezimbi zilandelayo:

• migraine;
• samathambo psoriatic;
• tenosynovitis;
• yokulunywa sezintso;
• samathambo gouty;
• bursitis;
• dorsalgia;
• myalgia;
• isifo samathambo;
• media otitis;
• osteoarthritis kwasendaweni ezahlukeneyo;
• polymyalgia rheumatica;
• ubuhlungu bone;
• sciatica;
• phlebitis;
• ankylosing spondylitis;
• neuralgia;
• thrombophlebitis;
• sciatica;
• adnexitis;
• Pathology kwi plexus lumbosacral;
• sciatica;
• algodismenorei;
• postoperative kunye yocalu-traumatic stress syndrome ;
• lymphangitis;
• iintlungu ezimbi umhlaza.

Thenga ichiza "Flex", ixabiso apho kuyahlukana ku ezahlukene 200-300 engange, ukuba unalo engumyalelo na ekhemesti. Kananjalo kubalulekile ukuba siqaphele kukuba amakhandlela "Flex" kwi zuza nto ngokufanelekileyo idla ngokusetyenziswa zazo ezizikhethileyo kwezimiselweyo zohlobo cyst ovarian. Ngokutsho ubungqina izigulane ezininzi, iyeza lusebenza ngempumelelo. Oogqirha abaninzi bathi emva kokuba unyango "Fleksenom" iintsuku ezili-10 uze kufumana amachiza ezongezelelweyo cyst inyamalala.

Izimo

Ukuba ugqiba ekubeni usebenzise i 'Flex "(amakhandlela), umyalelo manual ibonisa ukuba eli chiza kufuneka zisetyenziswe kwezi meko zilandelayo:

• ukopha kwisiqwenga zesisu;
• ochazwa sezintso wesibindi kwekhono;
• ukukhulelwa kunye zisanyisa xesha;
• hypersensitivity kwi non-steroidal amachiza-ukudumba;
• hemorrhoids;
• "Aspirin" somoya;
• ukuphazamiseka of ekunqandeni igazi ;
• proctitis;
• ababudala bungaphantsi kweminyaka eli-15;
• kwekhono kwenkqubo hematopoietic (leukopenia, ukuphazamiseka coagulation, thrombocytopenia, kubazali);
• exacerbation isifo wamathumbu.

imiyalelo Special

"Flex" (amakhandlela) nezobekelo isikhokelo isetyenziswe ngobulumko xa izigulane kwekhono kwezintso, isibindi, wokugaya, isifuba inyumoniya, butywala, nokuthimliswa, xa polyp kwi ngeempumlo isifo, emzimbeni, urticaria, ukutshaya, ukuqina kwesibindi, hyperbilirubinemia, izifo igazi nokudumba, isifo seswekile, ezimbi spinal, abantu abakhulileyo. Ngexesha unyango kunye medicament wathi ufuna ukusebenzisa indlela yokuhlola umsebenzi kwezintso nesibindi. Ukuba i "Flex" amakhandlela amisiweyo ngokuhlangeneyo kunye anticoagulants (lweeHedfowuni), nengozi enkulu ukopha. Ikhosi elide elapha kunokwenzeka kuphela kwiimeko apho esibhedlele. Ngexesha unyango, uphephe iziselo ezinxilisayo.

effect side

Eyabelwe kuwe "Flex" (namakhandlela)? Imiyalelo Sebenzisa akukhethi uphuhliso yeziphumo ebezingalindelekanga. Zezi:

• enentloko engapheliyo;
• isicaphucaphu;
• heartburn;
• nesiyezi;
• ukuphalaza;
• ukulahleka emnyama;
• ugwayi;
• yokopha zesisu;
• asthenia;
• ukozela;
• conjunctivitis;
• xerophthalmia;
• uvalo;
• nokuqunjelwa;
• ukuduma;
• ekukhohlweni;
• ukungaboni;
• hepatitis;
• ubuthulu;
• vertigo;
• peripheral neuropathy;
• gastralgia;
• tachycardia;
• dysuria eziphelayo;
• siwasebenzise;
• onokhwekhwe;
• Ngokuzimela;
• syndrome nephrotic;
• urethritis;
• fotodermatit;
• nokudumba laryngeal;
• hematuria;
• erythema;
• kwekhono sezintso;
• nokudumba syndrome ;
• isikhumba silume;
• aleji;
• ukwanda transaminases (alanine aminotransferase kunye aspartate aminotransferase) e serum igazi;
• ukuphelelwa umoya;
• nokuthimliswa;
• nokopha;
• bronchospasm;
• yashiya anaphylactic.

Ukusetyenziswa suppositories zinokubangela urhudo, tenesmus kunye imvakalelo otshisayo.

Iimpawu ku libanda

Amakhandlela "flex" ilungiselelwe ukusetyenziswa efakwa - suppository 1 (100 mg) izihlandlo 1-2 ngemini. Ubuninzi umthamo avumelekile yemihla ngemihla ketoprofen - 300 mg. Ezi mpawu zilandelayo kuvandlakanywa kwimeko libanda:

• kwekhono wesibindi, nezintso;
• ukozela;
• isicaphucaphu;
• ukopha;
• buhlungu kakhulu kule ngingqi epigastric;
• ukubuyisa.

Xa uzingela iimpawu ngentla eyabelwe unyango nomqondiso. Akukho iyeza ngqo. Njengoko i adsorbent iyasebenza amalahle, "Sorbeks", "Medetopek" okanye "Neointestopan". Dialysis, diuresis ngenkani - unyango alusebenzi. Faka arhente alkalizing eququzelela inxalenye iimpawu umsele alimentary. glucocorticoids anokusetyenziswa xa kuyimfuneko. Xa insufficiency kwezintso, olugqitha esikhumbeni. Xa unditsho amisele "Diazepam" benzodiazepanovye okanye ezinye iziyobisi anticonvulsant; e ababambeleyo hypotension plasma kakhulu ilawulwa ( "Reopoligljukin", "Poliglyukin", "Enterodez", "Polidez", "Hemodez"). Isigulane ifuna ukuqwalaselwa rhoqo iintsuku ezimbalwa, njengoko kukho ingozi ekubonakalisweni kamva ukuphazamiseka ezithile zesisu (ukopha, izilonda).

Intsebenziswano kunye namanye amachiza

It kwandisa sisenzo anticoagulants, fibrinolytics, ethanol, arhente antiplatelet, kunciphisa ifuthe vasodilators peripheral, spironolactone, ubuchule amayeza uricosuric, namayeza afanelekileyo kunye womchamo iqinile. Ngaphezu thaca amayeza ingahimbiselani "Tramadol." Ukusetyenziswa idibene "Flex" kunye nabanye abasebenzi abanga-steroidal arhente anti-ukudumba, ethyl utywala, corticosteroids, corticotropin kuphakamisa ukuyilwa izilonda kunye nophuhliso ukopha zesisu. Asidi ukunciphisa nocikizeko kukufakwa ichiza. Kwiintsuku ezimbini phambi kokuba unikezelo wohlalutyo kwi ngokuqulethwe ichiza-ketosteroids 17 yabhukuqa.

"Flex" kwandisa isiphumo hypoglycemic kwencindi kunye neziyobisi ngomlomo hypoglycemic. amachiza Myelotoxic ukwandisa ibinzana iziyobisi gematotoksichnosti. Inductors microsomal biooxidation esibindini ( "phenylbutazone", ethanol, lakhula tricyclic, "Phenytoin", "rifampicin" barbiturates) isebenze biosynthesis of metabolites esebenzayo hydroxylated. isicelo ngaxeshanye "lukwazi" ne "sodium valproate" ebangela kuphazamisa zegazi udibaniso.

Izimvo kulungiselelwa

Izigulane ezininzi anomdla umbuzo noko ke kwamakhandlela "flex". Imiyalelo zokusetyenziswa, iindleko ichiza, kubonakala kunye Izimo - oko kukuthi, Kakade ke, iingongoma eziphambili. Nakuba kunjalo, kufuneka baziqhelanise iimbono zeengcali kunye nezigulane kule nkalo. Oogqirha abaninzi bakholelwa ukuba iintlungu ilungileyo arhente anti-ukudumba - "lukwazi ukumelana" (amakhandlela). Iimpendulo zabo izigulane kwiimeko ezininzi (80 to 90%) ngabona HIV, ngenxa ukusebenza eliphezulu ichiza, ntlungu umyalezo ethembekileyo ezahlukeneyo zalapha, isiphumo kunye usebenziso olulula oluhlala luhleli. A nemiphumo emihle onokubonwa ukususela kwimihla yokuqala yokwamkelwa. ukubuyekeza ezimbi malunga ukulungiswa kakhulu enxulumene inkangeleko yeziphumo ebezingalindelekanga kunye neendleko zalo, kodwa ezi bendlela amayeza abakwazi ukuba zithathele ukusebenza kwayo phezulu.

Iimeko yonikezelo ezikhemesti

Ichiza ngokohlobo suppositories kunye njengezingxobo wakhululwa ngqongqo kagqirha. A medicament ngohlobo yejeli kunokwenziwa uyasuswa ngaphandle kagqirha.

iimeko yokugcina

Gcina ingafumaneki abantwana lobushushu akukho ngaphezulu kwe 25-30 ° C. Le lebanga lobushushu ibhekisa zonke iintlobo ukukhululwa. Umhla wokuphelelwa ekwibhokisi. Imithi kufuneka kuthathwe emva komhla wokuphelelwa!