Fluticasone furoate: imiyalelo ukusetyenziswa, analogs kunye nohlolo

Kuba unyango iinkqubo ukudumba ezenzeka emzimbeni womntu kuzo zombini ifomu etsolo kwaye ezingapheliyo, oku kusetyenziswa iintlobo ezininzi iziyobisi. Ezinye uhlobo nonsteroidal, ukuba abanye ezinxulumene ngqo iihomoni.

Kwi ichiza abachaphazelekayo?

Iqela yokugqibela iziyobisi ngempumelelo ngayo nangokurhala, ibhekisela flukatikazona furoate. Triftorirovannoe Le compound walungisa izithako. Ngobume bayo, iziyobisi bobabo kwiqela hormone glucocorticoids. Icandelo chiza a endibuthethileyo ngokwaneleyo isiphumo anti-ukudumba. Ukuba inqanaba eliphezulu affinitivnosti ukuya receptors glucocorticoid, oko kuchaphazela iindidi ezahlukeneyo iiseli, ezifana macrophage, lymphocyte, eosinophils, kunye nabanye. Kwakhona phantsi kweempembelelo yabalamli nangokurhala, ezizezi, chemokines kunye cytokines.

Indlela ukungena umzimba?

Le peculiarity yale kuqulunqo kukuba furoate flukatikazona ayikwazanga engenakufunxwa ngokupheleleyo ngumzimba ziye umzimba sisibindi. Ngenxa yoko, le nto iphawulwa kukungakhuseleki buthathaka systemic.

Kukho ezi fom zilandelayo zokusetyenziswa ichiza:

• ulawulo Intranasal. Ngale ndlela unyango kunye neziyobisi bioavailability yayo ixhomekeke balawule. Ukuba ekuthatheni kuthetha micrograms 110 ngosuku, umxholo wayo egazini okunene andibhaqwa. Kwimeko ezithatha ichiza xa kukho umthamo 880 mg izihlandlo ezithathu ngamnye iiyure ezingama-24, bioavailability yayo 0.5%;
• Ukuba uthatha flukatikazona furoate inhalation, sisalathisi bioavailability yalo 27.3%.

Kwakhona, ichiza zingasetyenziswa ngomlomo kwaye yegazi.

Eli chiza enebana iiproteni plasma kunye kwisalathiso 99% okanye ngaphezulu. Yaye idityaniswe iiseli ezibomvu ayinamsebenzi. Flukatikazona furoate kakhulu umzimba ngempumelelo esibindini kwaye enzymatically Ndinamathele izinto engeyongozi ekubhekiselwe fluticasone. Eli chiza ndawo ngokukhawuleza ushiya egazini. Ukuba iyeza sithathwa ngomlomo okanye butofelwe, luthe lwancothulwa phantse ngokupheleleyo enyongweni ukusuka emathunjini kunye inxalenye omncane kwazona yi nezintso.

ubungqina

Fluticasone furoate, umyalelo apho ngokuyimfuneko ihamba iphakheji amayeza, siboniswa ezi zifo zilandelayo:

• Unyaka-round uyalisa nokuthimliswa umlinganiswa.
• isifo Obstructive pulmonary, kuquka ezingapheliyo.
• isifuba inyumoniya - nokulondolozwa unyango zidityanisiwe.

Ukuba unayo syndromes ichazwe ngokucacileyo, echaziweyo ngentla, iimveliso ezisekelwe kule Isithako asebenzayo ngempumelelo ukujongana nawo. Kodwa musa ukulibala ukuba into ebalulekileyo malunga fluticasone furoate, nto leyo a hormone. Misa kuphela ugqirha wakho isiyobisi enjalo.

Izimo

Le mveliso zoxubo mayeza lineqela Izimo kunye nezithintelo nokusetyenziswa. It ingenakuthatyathwa kwezi meko zilandelayo:

• Hypersensitivity ukuba eyona nto engundoqo esebenzayo.
• Abantwana abangaphantsi kweminyaka eli-18 (ngaphandle ingcebiso kagqirha okhethekileyo kaThixo).

Le miba ngokunciphisa ukuya yokwamkela eli chiza kungaba:

• Isibindi kwekhono.
• tuberculosis miphungeni.
• Izifo ezosulelayo akukho sinyangeke ngokupheleleyo, okanye ifomu ezigulo ezondeleyo.

Ngokuphathelele isikhundla ukuba kunokwenzeka ukuba abasetyhini abakhulelweyo kunye phindeke, fluticasone furoate, imiyalelo zokusetyenziswa zibonisa ukuba olu lwazi akwanelanga. Eli chiza kufuneka isetyenziswe kuphela kwiimeko apho umngcipheko olungekazalwa okanye womntwana ongaphantsi neziphumo ezilindelekileyo elihle unina.

imiphumela emibi

Imiyalelo zokusetyenziswa abonisa iziphumo ebezingalindelekanga olude olunzulu kweli chiza, oko kuxhomekeka ezahlukeneyo isicelo sayo. ukusetyenziswa kweziyobisi Intranasal, ukuba ichazwa ngolu hlobo lulandelayo:

• Ukungaqheleki kule isixokelelwano sokuphefumla: ukopha impumlo, imbonakalo yakhe phezu izilonda mucosal.
• ziyabagulisa: ukungxama emzimbeni, angioedema, anaphylaxis, urticaria.

Ukuba fluticasone furoate, nto leyo kwakhona becala HIV, lusetyenziswa kwimo inhalation of indibanisela-lohlobo amalungiselelo, iziphumo ebezingalindelekanga zilandelayo zenzeke:

• Diseases nature ezosulelayo: umkhuhlane, inyumoniya, iphika kunye nezinye izenzakalo ezifanayo iphecana eliphezulu zemiphunga. Kusenokwenzeka kwakhona ukuphuhlisa candidiasis oropharyngeal.
• Yokuphazamiseka ekusebenzeni eqhelekileyo inkqubo yokuphefumla, leyo ungaboniswa ngokohlobo intlungu oropharyngeal, nasopharyngitis, sinusitis, pharyngitis, khohlo, dysphonia, kunye sinusitis.
• Izifo nokuqina kunye skeletal izihlunu kwezihlunu: kwizaphuko, arthralgia, iintlungu apha ngasemva.
• Usenokuba kwakhona iintlungu esiswini, uqaqanjelwa, izenzakalo febrile, ibetha, glaucoma, sinciphise kwamathambo, ukusebenza odandathekileyo lwenkqubo ngxenye-yebhinqa-adrenal, ukukhula kwamathuba emfundo abantwana nabo bakwishumi elivisayo, cataract.

Njani isicelo nokuba kangakanani?

Spray "Fluticasone furoate" ingahoywa intranasally kanye emini. Kwakhona, ichiza ingasetyenziswa xa inhalation kumalungiselelo idityaniswe. Le umthamo iyeza emiselweyo ngokuxhomekeke kubudala lomguli ukususela 27.5 ukuya 55 mcg. Ukugcina ukufumaneka emiselweyo esebenzayo kweziyobisi 27.5 mg yokulungiselela.

Nabavelisi iimveliso yamayeza wamlumkisa ukuba ngexesha unyango kunye ichiza kufuneka zilumke ekuphunyezweni kwemisebenzi kunye yingozi. Ezi ziquka izenzo ezifuna ingqwalasela eyodwa kwaye reactions lengqondo fast, ezifana lokuqhuba isithuthi okanye yokusebenza oomatshini.

imithi

Ukuba ukusetyenziswa ehamba fluticasone furoate ketoconazole kucetyiswa isilumkiso.

Kananjalo akukhuthazwa ukuba ngaxeshanye co-lezolawulo "ritonavir". Oku kungenxa kumngcipheko yokuqinisa lwenkqubo fluticasone furoate.

libanda

I engekho mthethweni study data amathuba libanda, izigulane bafumana ithamo amakhulu Kunconywa izihlandlo ezingama-24, kwithuba ixesha leentsuku ezingaphezulu kwama-3. Ngenxa yoko, kwakungekho bungqina ukwenza izinto ezimbi lwenkqubo. Kodwa ke abenzi bamachiza ziye wamlumkisa ukuba isenzo glucocorticoids babe uphuhliso. Kule meko kukho imfuneko kweliso unyango kunye nonyango olufanelekileyo esekelwe iimpawu.

amalungiselelo

Kukho iziyobisi eziliqela, iyeza esebenzayo engundoqo leyo fluticasone furoate kwiimveliso zoxubo mayeza kwi emarikeni: "Avamys", "Flutisan", "Nazofan", "Flutineks", "Seroflo", "Flohal" yaye "Fleksonaze". Eyona ndlela popolyarnym le layini yeyona arhente lokuqala igama. "Avamys" fluticasone furoate iquka njenge yinto ephambili esebenzayo kwaye iyafumaneka isitshizi elula.

"Avamys"

Esi sixhobo iye yaba ngokwayo ngecala ngcono ukunyanga nokuthimliswa komzimba. Kule sifo, kukho nje iindumbisa le isifo ngeempumlo kunye ukubhobhoza lweenkcukacha kulowo, kodwa ngohlobo ezibonisa ocular kujuba, ukurhawuzelela, ububomvu kunye njengokungathi ntofontofo "intlabathi". Oku kunciphisa kakhulu iimpawu umgangatho wobomi ngemihla, oko iba nefuthe elibi sibe kwaye ikhokelela imali ebonakalayo xa unyango. Izazinzulu ziye zafumanisa ukuba esona sizathu siphambili obubonakala komzimba ikhonza excitation luvo parasympathetic ekukhutshwa ukudumba mediators isifo le sinuses. Ekubeni zonke iimpawu nokuthimliswa komzimba ukhona iziyobisi "Avamys." Fluticasone furoate, kubandakanywa ukwakheka yayo ibe yinto ephambili esebenzayo, enza izinto ezinale analyzers receptors ezithintela ngenxa yokusabela yomzimba bomntu zamavumba nezidlo. Ngoko ke, zonke iimpawu kabi ngisho amandla ngokuyinqaba kwaye nomgangatho yomguli ngayo ubomi ngcono kakhulu. Ngenxa yokuba eli candelo ephambili unalo oludla eliphezulu receptors, eziwafaka uba robust kakhulu yaye yanyamezela yahlala ithuba elide, nto leyo enika ukusebenza ixesha elide yokulungiselela.

zonke Izimo kunye neziphumo ebezingalindelekanga ichiza olunxulumene ngqo into yokuba into esebenzayo lithetha "Avamys" - furoate fluticasone, imiyalelo apho zinikwe ngentla. Uyalumkisa ukuba imveliso hormone zoxubo ingenakuthatyathwa ngaphandle kagqirha kagqirha.

iimveliso kolimo

Takzhedlya unyango lwe nokuthimliswa komzimba, COPD kunye isifuba inyumoniya sokukhomba zidityanisiwe amalungiselelo eziqulathe fluticasone furoate, vilanterol kunye amanye amacandelo abancedisayo. Edume kakhulu kwilizwe lethu ufana amayeza "Relvar Ellippta". Le mveliso zoxubo mayeza iqulethe izithako ezisebenzayo kwi ezixinene zilandelayo ithamo nganye:

• furoate fluticasone Micronised, 100 mcg.
• Vilanterola trifenatat micronized 40 g.

Eli yeza iza ngohlobo ngumgubo enemitha ukuba inhalation. It has a imiphumo anti-ezithintela ukosuleleka kunye bronchodilator libizwe. "Relvar Ellippta" libhekisela kuthetha ukuba isiphumo bronchodilator, ngokuba izithako ezisebenzayo ke nxada: a uyakhetha beta--agonists-2, kunye glucocorticosteroid basekuhlaleni.

Ngokutsho ubungqina zonyango echiza:

• isifuba inyumoniya, apho indlela eyayisetyenziselwa impilo yesondlo.
• Obstructive isifo yemiphunga kwifom ezigulo ezondeleyo (COPD). Kulo mzekelo, lokufunyaniswa unyango ngamachiza unga nciphisa ngokubaluleka exacerbations.

kweziyobisi okuchazwe senzelwe kuphela inhalation ukuba ziveliswa kanye ngosuku ngexesha elithile (ngokuhlwa okanye ekuseni). Abavelisi bacebisa ukuba emva kokuba inkqubo, pula umlomo ngamanzi, kodwa musa uyaziginya.

Izigulana nesi sifo kufuneka uthathe ichiza, kungakhathaliseki ukuba ubukho iimpawu zesifo ngokukhawuleza. Ukuba ikhefu phakathi kwizifundo zonyango kukho izinto ezicacileyo esi sifo, ugqirha ngokuqhelekileyo onyula beta _agonists-2 inyathelo elifutshane ngohlobo inhalations. Oyidlayo ukhetha kuphela ugqirha khona.

Le lamanani zilandelayo zezithako ezisebenzayo (vilanterola trifenatat kunye flukatizona furotat ngokulandelelana) linokukwenziwa abantu abadala kunye nabantwana abangaphezu kweminyaka eli-12 ngo-nye inhalation / 1 Ixesha ngosuku:

• 22 g + 92 g;
• 22 .mu.g + 184 mg.

Kwedosi yokuqala unikwe ugqirha kwabo izigulane abadinga ineqondo eliphantsi okanye eliphakathi lamanani kwezinto esebenzayo, ngokunjalo kuzo ukunyanga COPD abadala. Kufuneka kuqatshelwe ukuba, ngenxa yonyango engapheliyo isithintelo wemiphunga ebantwaneni ingasebenzi. Esithathwa efanayo emiselweyo kubantu nokuphazamiseka ewasusa avareji.

Uhlobo lwesibini umthamo emiselweyo kwizigulana abafuna izinga kwezinto esebenzayo unyango besi sifo, xa umthamo omncinane ayinalo yifuna.

Abantu kwiminyaka engama-65 ubudala, kwakunye nabo babe isifo nezintso, xa ulungiso ichiza awudingi.

Ukuze usebenzise le amayeza ezisebhokisini kukho inhaler eyodwa na bokuqonda ukusebenza kunye nolondolozo. Zichazwe ngokucacileyo imiyalelo phambi kokuba ukusetyenziswa kwaye kufuneka ukuba bahlole isifinyezo ngenyameko.

iziphumo ebezingalindelekanga ichiza inokuchazwa kule fom zilandelayo:

• Lidla: eliphezulu zemiphunga usulelo phecana, umkhuhlane, candidiasis oropharyngeal, inyumoniya; migraine; arrythmia; nasopharyngitis, sinusitis, nokuthimliswa, hoarseness, ukukhohlela; walunywa; iintanda, arthralgia, iintlungu apha ngasemva; umkhuhlane.
• Ngamanye amaxesha nazo: hypersensitivity, irhashalala, angioedema, urticaria, anaphylaxis; ixhala yokudla; lafa; tachycardia.

Izimo ekusebenziseni "Relvar Ellippta" zezi:

• Andidibani obisi okanye naliphi na kumacandelo ichiza.
• Abantwana ukuya kwiminyaka engama-12.

Ngokukhathalela le mveliso zoxubo mayeza kufuneka zithathwe kwizigulane kunye nezifo sentliziyo osudistymi kakhulu, kunye nesifo sephepha yemiphunga kunye nezifo ezingapheliyo esosulelayo.

Abafazi abakhulelweyo emiselweyo ichiza kuphela kwiimeko xa umbuzo malunga iinzuzo unina, mkhulu umngcipheko olungekazalwa. Xa zisanyisa imithi alawulwa ngokudibene ukungahoywa lokuncancisa kunye ukuphelisa lomngcipheko umntwana.

Ukusetyenziswa ehlanganyelwayo ichiza "Relvar Ellippta" kunye beta-blocker kufuneka luthintelwe, ngaphandle apho kuyimfuneko. Kwakhona kubalulekile ukuba unonophele ukuya nodibaniso 'Ketoconazole "yaye" ritonavir ".

analogs

Ukuba unyango nokuthimliswa komzimba, COPD okanye isifuba, ukuze yabelwe fluticasone furoate, analogs kweli chiza onokuba eyamkelekileyo. Nomniki-nyango wakho ngokusekelwe iimpawu ngamnye kumzimba, amisele ichiza ekunene. Phakathi analogue beziyobisi ziquka:

• "Asmaneks";
• "Aurobin";
• "Garazon";
• "Deksapos";
• "Karizon";
• "Abistan";
• "Beklat" kunye namanye amayeza ezivela iqela elifanayo zoxubo mayeza kunye flukatizona furotatom.

Musa ukulibala ukuba amayeza kufuneka kwenziwe kuphela xa kagqirha, yaye kuphela emva kwesifundo ngenyameko imiyalelo.