Isifo sikaCushing - isifo esinokuxhatshazwa kwintsimbi ye-pituitary

Isifo sikaCushing okanye i-Itenko-Cushing sisifo esibangelwa ukuphulwa kwemisebenzi ye-hypothalamus, i-pituitary gland kunye neengqungquthela ze-adrenal kunye nokuphuhliswa kweengxaki zentsholongwane. Esi sifo saqale sachazwa nguN. Itenko ngo-1924, kwaye ngo-1932 uCushing waxhuma ukukhula kwakhe kunye ne- adenoma ye-pituitary.

Izizathu zokuphuhliswa kwesifo se-Itenko-Cushing yi-adenoma ye-basophilic ye-lobe yangaphambili ye-pituitary gland okanye ukwanda kwenani leenjenge-basophilic ze-pituitary gland. Ezi nguqu zinokuvela ngenxa ye-craniocerebral and psychic traumas, i-encephalitis, i-endocrine disorders.

Kwintliziyo yokuphuhliswa kwesi sifo kukuvelisa i-hormone ye-adrenocorticotropic, eyenza ukwanda kwindlela yokuqhafaza i-cortisol.

Isifo sikaCushing-picture clinic

Esi sifo siphuhlisa kancane. Izigulane zikhalaza ngokubonakala buthathaka, ukulala, ukunganakwa, ukunyamezela. Ukunyamekela kubaluleke kakhulu kwisiqingatha esiphezulu sesiqu. Ngenxa yoko, izigulane zenza ubuso obunenyanga, amahlombe apheleleyo, iinqabunga, ngokungahambisani nendawo, kunye nemilenze. Kukhona ukoma kunye nokwehliswa kwesikhumba, isifo somntu esisetyhini kubafazi, kunye nokulahleka kwentloko kwintloko, kwindoda yabesifazane. Kwisikhumba seesisu, amahlombe, iingqungqumbo zesifuba zivela kwiindawo ezininzi ezibomvu ezibomvu. Ngokuhamba kwexesha, i-atrophy ye-muscle ikhula kwimilenze, amandla abo ancipha. Uxinzelelo lwe-arterial uhlaselwa ngumonakalo wento, iingxaki zeengqondo kunye nophuhliso lwe-atherosclerosis.

Isifo sika-Itenko-Cushing sikhokelela ekuphazanyisweni kwe-mineral metabolism, okubangelwa kukuphuhliswa kwe-osteoporosis. Ngenxa ye-osteoporosis, iingcambu zentsholongwane ziyafuduka kwaye zidibene, intlungu enzima emilenzeni, umlenze, ukukhawuleka kwentlambo ye-thoracic iqala ngokubunjwa kwe-kyphosis, i-fractures. Igazi liphakamisa umxholo we-calcium kunye ne-cholesterol. Ukuxutywa kwe-glucose kuvalwe, ngenxa yoko isifo sikashukela sikhula. Ukwandisa ukukhula kwegazi, ukuphilisa amanxeba. Izigulane zikhalaza ngokuphulwa komsebenzi wesondo, ukunciphisa i-libido kunye nefuthe, kukho ukuphazamiseka komjikelezo wesini. Iingxaki ze-neurosis, ukudandatheka, i-hypochondria, i-psychosis.

Kusuka entliziyweni kuvela i- ventricular hypertrophy, tachycardia, isifo esichengeni segazi esichengileyo. Ekuhlolisweni kweentso, iproteinuria, ukuhla kwehliswa kwe-glomerular kunye nesantya sokuhamba kwegazi. Uphuhliso olunokwenzeka lwe-nephrosclerosis ngokungabikho komsebenzi walezi ziko. Kwezinye izigulane, amatye afunyanwa kwizintso.

Ukuxilongwa kwesi sifo

Isifo sikaCushing sifumaneka ngombala we-skull nge-skull efundwe ngesikhephe saseTurkey, i- tomography yeckull kunye ne-adrenal glands, kunye ne-angiography. Iimvavanyo zeLebhanon zenza umgangatho we- hormone cortisol egazini kunye nemali ye-corticosteroids kumchamo.

Isifo sikaCushing - unyango

Ukukhethwa kwendlela efunekayo yonyango ngokuyinhloko kuxhomekeke kwisizathu sokuphuhliswa kwesi sifo kunye nokubaluleka kwezibonakaliso zeklinikhi zesifo.

Kwizigaba zokuqala zokumisela imishanguzo eyanciphisa ukwenziwa kwe-horrenone ye-adrenocorticotropic kunye ne-corticosteroids. Basebenzisa iziyobisi ezinqamlekileyo, unyango olungumqondiso. Inkqubo yeyeza unyango ihlala kwiinyanga ezilisibhozo. Ukungabikho komphumo, iifom ezinzima zesifo, intsebenziswano yonyango equkethe unyango lwe-radiation kunye ne-intervention intervention (ukususwa kwe-pituitary gland okanye i-adrenalectomy) imiselwe.